A nurse is caring for a 40-year-old female client in an outpatient clinic. The client is at risk for developing __________ and _________.

The client is at risk for developing hallucinations and weight loss. Rationale for correct answers: Bupropion is an atypical antidepressant used for smoking cessation that acts by inhibiting the reuptake of norepinephrine and dopamine. It is known to potentially cause neuropsychiatric side effects, including hallucinations, especially in patients with a history of psychiatric disorders such as bipolar disorder. Weight loss is a common adverse effect due to bupropion’s appetite suppression and increased metabolism. Normal weight is assessed by BMI, and this client has a normal BMI, but bupropion may exacerbate weight loss. Hallucinations indicate serious CNS involvement and require close monitoring. Rationale for incorrect Response 1 options: Dependence is not typically associated with bupropion; it has a low abuse potential. Somnolence or drowsiness is not a prominent side effect; bupropion is generally stimulating rather than sedating. Hypotension is also not a common effect; bupropion may actually increase heart rate and blood pressure slightly. Rationale for incorrect Response 2 options: Somnolence is not common; patients may experience insomnia rather than sedation. Hallucinations are already selected as a correct response. Hypotension is rare; instead, bupropion can cause hypertension in some cases. Weight loss is a known side effect and thus the correct choice. Take home points: Bupropion can cause neuropsychiatric side effects, especially in clients with bipolar disorder. Weight loss may occur due to appetite suppression and increased metabolism. Monitor closely for CNS symptoms such as hallucinations during therapy. Smoking cessation pharmacotherapy must be tailored considering psychiatric history to avoid adverse effects.