A nurse is caring for a client hospitalized for major depressive disorder who states, "I've made so many mistakes in life. My family would be better off without me." Which of the following is the most therapeutic response by the nurse?

Rationale: A. While this question opens communication, it shifts the focus to others instead of validating the client’s current emotional state. B. This is a nontherapeutic response that minimizes the client’s feelings and offers false reassurance. C. This can evoke guilt and is not therapeutic—it shifts the focus away from the client’s emotions and may increase their distress. D. This response demonstrates empathy, acknowledges the client’s emotional pain, and shows willingness to listen—a cornerstone of therapeutic communication.