A nurse is caring for a client that will receive a diuretic. Which of the following diuretics act on the distal tubule?

Choice A rationale Furosemide is a loop diuretic that acts on the ascending limb of the loop of Henle, not the distal tubule. Choice B rationale Spironolactone is a potassium-sparing diuretic that works on the collecting ducts and late distal tubules, not the distal tubule. Choice C rationale Mannitol is an osmotic diuretic that acts on the proximal tubule and the descending limb of the loop of Henle, not the distal tubule. Choice D rationale Hydrochlorothiazide is a thiazide diuretic that works on the distal convoluted tubule, making it the correct answer.