A nurse is caring for a client who has a bloodstream infection caused by a multidrug-resistant organism (MDRO). The nurse is preparing to administer intravenous vancomycin. Which action should the nurse take to reduce the risk of nephrotoxicity?

A. Nausea and vomiting are not primary indicators of vancomycin nephrotoxicity. While any adverse reaction should be assessed, stopping the medication solely for mild gastrointestinal symptoms does not prevent nephrotoxicity and could compromise treatment of the infection. B. Flushing the intravenous line with 0.9% sodium chloride before and after administration – Flushing the IV line helps maintain patency and prevent line occlusion but does not reduce the risk of nephrotoxicity associated with vancomycin. C. Vancomycin is nephrotoxic, and its toxicity is dose- and duration-dependent. Monitoring renal function through serum creatinine and BUN before each dose allows early detection of kidney injury. Adjusting the dose or timing based on these lab results helps prevent significant nephrotoxicity while ensuring therapeutic effectiveness. D. Vancomycin should never be administered over 15 minutes because rapid infusion increases the risk of "red man syndrome," a histamine-mediated reaction. Infusions are typically given over at least 60 minutes (or longer for higher doses). While this action reduces infusion-related reactions, it does not address nephrotoxicity.