A nurse is caring for a client who has a new diagnosis of major depressive disorder. Which of the following medications should the nurse expect the provider to prescribe to the client as a first-line treatment?

Choice A reason: Midazolam is a benzodiazepine used for sedation and anxiety, not for treating depression. It is not appropriate as a first-line antidepressant. Choice B reason: Fluoxetine is an SSRI and is commonly prescribed as a first-line treatment for major depressive disorder due to its efficacy and favorable side effect profile. Choice C reason: Cyclobenzaprine is a muscle relaxant used for musculoskeletal conditions. It has no indication for depression treatment. Choice D reason: Valproic acid is a mood stabilizer used primarily for bipolar disorder and seizure management. It is not a first-line treatment for unipolar depression.