A nurse is caring for a client who has a new prescription for clozapine. Which of the following should the nurse recognize as an adverse effect of this medication?

A. Diarrhea: Diarrhea is not a common adverse effect of clozapine. Gastrointestinal symptoms may occur with some antipsychotics, but diarrhea is not a primary concern with clozapine therapy. B. Hypoglycemia: Clozapine is more commonly associated with hyperglycemia and increased risk of diabetes mellitus, rather than hypoglycemia. Blood glucose monitoring may be needed in clients at risk. C. Agranulocytosis: Clozapine can cause severe neutropenia or agranulocytosis, which increases the risk of infection. Regular monitoring of white blood cell counts is essential, and any signs of infection should prompt immediate evaluation. D. Urinary frequency: Urinary frequency is not a typical adverse effect of clozapine. Anticholinergic effects like urinary retention are more commonly associated with this medication, rather than increased frequency.