A nurse is caring for a client who has been prescribed clozapine. Which of the following topics should the nurse prepare to discuss with the client?

A. Tyramine restrictions are associated with MAO inhibitors, not clozapine or other antipsychotics, so dietary counseling about tyramine is unnecessary for this medication. B. While medication adherence is important for all antipsychotics to prevent relapse of psychosis, clozapine’s teaching priorities focus more on safety monitoring for serious adverse effects rather than adherence alone. C. Limiting fluid intake is not a standard precaution for clozapine; hydration is generally encouraged unless there are specific comorbidities requiring fluid restriction. D. Clozapine carries a risk of agranulocytosis, a potentially life-threatening drop in white blood cells that can increase susceptibility to infections. Clients must undergo regular complete blood counts (CBCs) and absolute neutrophil count (ANC) monitoring, initially weekly, then gradually spaced to every 2–4 weeks if stable, to detect hematologic complications early. Educating the client on this requirement is essential to ensure safe, effective, and compliant use of the medication.