A nurse is caring for a client who has been prescribed isoniazid for tuberculosis for three weeks. The client reports a numbness and tingling sensation in the lower extremities. Based on the client’s presenting symptoms, which of the following is a complication of this medication?

A. Incorrect: Deep vein thrombosis (DVT) is not a known complication of isoniazid. B. Incorrect: Hemorrhage is not associated with isoniazid. C. Correct: Isoniazid can cause peripheral neuropathy due to vitamin B6 (pyridoxine) deficiency. Clients experiencing numbness and tingling should be assessed for neuropathy and may need pyridoxine supplementation. D. Incorrect: Achilles tendon rupture is a complication of fluoroquinolones, not isoniazid