A nurse is caring for a client who has diabetes mellitus and pulmonary tuberculosis, and a new prescription for isoniazid. The client reports tingling and numbness of the hands and feet. The nurse should expect which of the following drugs to prevent this adverse effect of INH?

A. Incorrect: Cyanocobalamin (vitamin B12) is used to treat pernicious anemia, not INH-induced neuropathy. B. Correct: Isoniazid can cause peripheral neuropathy by depleting vitamin B6 (pyridoxine). Supplementing with pyridoxine prevents this adverse effect. C. Incorrect: Vitamin K is used for warfarin reversal and does not prevent neuropathy. D. Incorrect: Protamine sulfate is an antidote for heparin overdose, unrelated to INH therapy.