A nurse is caring for a client who has HIV-1 infection and is prescribed zidovudine as part of antiretroviral therapy. The nurse should monitor the client for which of the following adverse effects of this medication?

A. Cardiac dysrhythmia: Zidovudine is not commonly associated with cardiac dysrhythmias. While some antiretroviral medications can have cardiovascular effects, cardiac dysrhythmia is not a significant or common adverse effect of zidovudine. B. Renal failure: Renal failure is not a primary adverse effect of zidovudine. Although certain antiretroviral medications can impact kidney function, zidovudine is generally not associated with renal failure. C. Aplastic anemia: Zidovudine can cause bone marrow suppression, which may lead to conditions like aplastic anemia. This is a known and serious adverse effect, and the nurse should monitor the client for signs of anemia, such as fatigue, pallor, and low hemoglobin levels. D. Metabolic alkalosis: Metabolic alkalosis is not a typical adverse effect of zidovudine. Zidovudine is more commonly associated with hematologic side effects like anemia and neutropenia, rather than metabolic disturbances such as alkalosis.