A nurse is caring for a client who has hyperlipidemia and a new prescription for colesevelam. The nurse should monitor the client for which of the following manifestations as an adverse effect of colesevelam?

Choice A rationale Colesevelam is a bile acid sequestrant that binds to bile acids in the intestine, preventing their reabsorption and promoting their excretion. This mechanism of action does not directly impact glucose metabolism or pancreatic function. Therefore, hyperglycemia is not a common or expected adverse effect of colesevelam. Choice B rationale Stomatitis is inflammation of the mucous membranes of the mouth, often presenting as oral sores. It is a potential adverse effect of various medications but is not a typical manifestation associated with colesevelam. The medication's primary site of action is within the gastrointestinal tract, not the oral mucosa. Choice C rationale A fever is a systemic manifestation of inflammation, infection, or other pathological processes. Colesevelam works locally within the gastrointestinal tract to bind bile acids and is not known to elicit a systemic inflammatory response that would cause a fever. Choice D rationale Colesevelam binds to bile acids, forming a complex that is excreted in the feces. This action can lead to gastrointestinal side effects. The non-absorbable resin can slow intestinal transit, leading to a common adverse effect of constipation. This is a direct consequence of the medication's mechanism.