A nurse is caring for a client who has posttraumatic stress disorder (PTSD) and is beginning psychopharmacologic therapy. Which of the following medications is considered first-line treatment for symptoms of PTSD?

Choice A reason: Sertraline is a selective serotonin reuptake inhibitor (SSRI) and one of the only FDA-approved medications for PTSD. It is considered first-line due to its efficacy in reducing core symptoms such as intrusive thoughts, hyperarousal, and avoidance. Choice B reason: Olanzapine is an atypical antipsychotic and may be used off-label for severe agitation or comorbid psychosis, but it is not a first-line treatment for PTSD. Choice C reason: Prazosin is used specifically to target PTSD-related nightmares and sleep disturbances. While effective for that symptom cluster, it is not considered a first-line agent for overall PTSD management. Choice D reason: Haloperidol is a typical antipsychotic primarily used for psychotic disorders. It is not recommended for PTSD due to its side effect profile and lack of efficacy in treating core PTSD symptoms.