A nurse is caring for a client who is participating in a research study for an experimental chemotherapy medication. After three doses, the experimental medication is discontinued due to evidence of rapidly advancing kidney failure. The nurse should understand discontinuing this medication demonstrates which of the following ethical principles?

Choice A reason: Autonomy refers to respecting the client’s right to make decisions about their own care. While autonomy is important in research, discontinuing the medication is not about client choice but about preventing harm. Choice B reason: Nonmaleficence means "do no harm." Discontinuing a medication that is causing kidney failure directly reflects this principle. The nurse and provider act to prevent further injury by stopping the harmful intervention. Choice C reason: Justice refers to fairness in treatment and distribution of resources. This principle is not directly demonstrated in the decision to stop the medication. Choice D reason: Fidelity refers to keeping promises and commitments. While important in research, fidelity is not the principle demonstrated in discontinuing a harmful medication.