N180 Pharmacology Proctored Exam
A nurse is caring for a client who is prescribed via intravenous (IV) route to treat a bacterial infection. The nurse understands that cefepime is a cephalosporin. and each generation of this medication class is more likely to reach the cerebrospinal fluid and is more effective against gram-negative organisms and anaerobes. What generation of cephalosporin is cefepime?
Explanation & Rationale
A. Incorrect: Second-generation cephalosporins (e.g., cefuroxime) have moderate gram-negative coverage but do not penetrate the cerebrospinal fluid (CSF) as effectively. B. Correct: Cefepime is a fourth-generation cephalosporin with broad-spectrum activity, better gram-negative coverage, and improved CSF penetration. C. Incorrect: First-generation cephalosporins (e.g., cephalexin) mainly target gram-positive bacteria. D. Incorrect: Third-generation cephalosporins (e.g., ceftriaxone) have better gram-negative coverage but less resistance to β-lactamases compared to fourth-generation cephalosporins.
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