A nurse is caring for a client who is taking clozapine for the treatment of schizophrenia. The nurse should monitor the client for which of the following potential adverse effects of clozapine?

Choice A reason: Dry mouth is a common side effect of many antipsychotics due to their anticholinergic properties, but it is not considered a serious adverse effect of clozapine. While it may cause discomfort, it does not pose significant health risks compared to other potential complications. Choice B reason: Hypoglycemia is not a typical adverse effect of clozapine. Clozapine is more commonly associated with metabolic syndrome, including weight gain, hyperglycemia, and dyslipidemia, rather than low blood sugar. Therefore, this option is incorrect. Choice C reason: Pain in the great toes is not a recognized adverse effect of clozapine. This symptom could suggest gout or another musculoskeletal condition, but it is unrelated to clozapine therapy. Choice D reason: Diarrhea is a potential adverse effect of clozapine. Clozapine can cause gastrointestinal disturbances, including diarrhea, constipation, and hypersalivation. Monitoring for these symptoms is important because they can affect the client’s hydration and nutritional status.