A nurse is caring for a client who is taking levothyroxine. Which of the following findings should the nurse identify as an adverse effect?

Choice A reason: Depression is not an adverse effect of levothyroxine. In fact, untreated hypothyroidism can cause depressive symptoms, which typically improve with appropriate thyroid hormone replacement. Choice B reason: Weight loss is the correct answer because levothyroxine increases metabolic rate. Excessive dosing or sensitivity to the medication can lead to hyperthyroid-like symptoms, including weight loss, tachycardia, anxiety, and heat intolerance. Choice C reason: Cold intolerance is a symptom of hypothyroidism, not an adverse effect of levothyroxine. Proper dosing should alleviate cold intolerance rather than cause it. Choice D reason: Constipation is also a symptom of hypothyroidism. Levothyroxine therapy generally improves bowel motility. Constipation is not considered an adverse effect of the medication.