A nurse is caring for a client who is taking prednisone for long-term treatment of rheumatoid arthritis. The nurse should monitor the client for which of the following adverse effects of this medication?

A. Liver toxicity: Prednisone is metabolized by the liver but is not commonly associated with hepatotoxicity. Liver function monitoring is not a primary concern for long-term prednisone therapy. B. Hemolytic anemia: Prednisone does not typically cause hemolytic anemia. Its primary hematologic effects involve immunosuppression rather than direct destruction of red blood cells. C. Hypoglycemia: Prednisone can increase blood glucose levels by promoting gluconeogenesis and reducing peripheral glucose uptake, which may lead to hyperglycemia rather than hypoglycemia. D. Bone loss: Long-term use of prednisone decreases calcium absorption and bone formation, increasing the risk of osteoporosis and fractures. Monitoring bone density and implementing preventive measures is essential for clients on chronic corticosteroid therapy.