A nurse is caring for a client who reports a headache and has a history of a peptic ulcer. Which of the following medications should the nurse administer?

A. Aspirin: Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that can irritate the gastric mucosa and increase the risk of gastrointestinal bleeding. It is contraindicated in clients with a history of peptic ulcer disease. B. Ketorolac: Ketorolac is a very potent Non-Steroidal Anti-Inflammatory Drug (NSAID) usually given IV or IM. It carries a high risk of GI ulceration and perforation and is contraindicated in clients with active PUD or a high risk of GI bleeding. C. Acetaminophen: Acetaminophen provides analgesic and antipyretic effects without significant gastrointestinal irritation. It is safe for clients with peptic ulcer disease, making it the preferred choice for headache management in this context. D. Ibuprofen: Ibuprofen, like other NSAIDs, can exacerbate peptic ulcer disease by inhibiting prostaglandin synthesis and increasing the risk of GI bleeding, so it should be avoided in clients with a history of ulcers.