A nurse is caring for a postoperative patient following a total knee replacement. Which of the following medications should the nurse anticipate the provider to prescribe to prevent the formulation of a deep vein thrombosis (DVT)?

A. Alteplase: Alteplase is a thrombolytic used to dissolve existing clots in conditions such as acute myocardial infarction, ischemic stroke, or massive pulmonary embolism. It is not used routinely for DVT prophylaxis because it carries a high risk of bleeding and is not preventive. B. Clopidogrel: Clopidogrel is an antiplatelet agent used primarily for arterial thrombotic conditions, such as prevention of stroke or myocardial infarction. It does not provide adequate prophylaxis against venous thromboembolism, which is more platelet-independent and coagulation-factor dependent. C. Warfarin: Warfarin is an oral anticoagulant that inhibits vitamin K–dependent clotting factors. While it can prevent DVT, it is not typically used immediately postoperatively due to delayed onset of action and the need for close INR monitoring. D. Enoxaparin: Enoxaparin is a low-molecular-weight heparin commonly prescribed postoperatively to prevent DVT, especially after orthopedic surgeries like total knee replacement. It acts quickly, inhibits factor Xa, and effectively reduces venous thromboembolism risk in high-risk surgical patients.