A nurse is caring for an adolescent in the outpatient dermatologist's office. Exhibits Complete the following sentence by using the lists of options. A nurse is providing education today on the newly-prescribed medication. The nurse recommends the adolescent notify the provider immediately if dropdownor dropdownoccurs during therapy.

Rationale for Correct Choices: A change in mood: Isotretinoin is associated with serious neuropsychiatric side effects, including depression, suicidal ideation, and other mood changes. Adolescents are at higher risk, and any mood alterations should be promptly reported to prevent adverse outcomes. Decreased night vision: Isotretinoin can cause visual disturbances, including decreased night vision. This side effect may impair safety (e.g., driving at night), and persistent or worsening symptoms warrant immediate medical evaluation. Rationale for Incorrect Choices: Nausea: While nausea can be a side effect of isotretinoin, it is not typically an urgent concern unless accompanied by signs of liver toxicity or pancreatitis. Mild nausea alone does not require immediate provider notification. The development of dry eyes: Dry eyes are a known and relatively common side effect of isotretinoin. They can typically be managed with over-the-counter lubricating eye drops and do not require immediate provider contact unless severe or persistent. Dry mouth: Dry mouth is not a significant or common concern with isotretinoin and, if present, can usually be managed with increased hydration and sugar-free lozenges. It is not an urgent finding. Worsening of acne: Acne often temporarily worsens during the initial weeks of isotretinoin therapy before improvement occurs. This is expected and not an indication to discontinue treatment or contact the provider urgently. Sunburn: Isotretinoin increases photosensitivity, making sunburn more likely. Clients should use sun protection, but sunburn itself does not typically require immediate provider contact unless severe. Engagement in sexual activity: Although sexual activity itself is not a side effect of isotretinoin, it is highly relevant for female patients due to isotretinoin’s teratogenicity. However, in this scenario with a negative hCG and no indication of sexual activity, this is a preventive counseling point rather than a reportable adverse effect.