A nurse is discussing antidepressants with a newly licensed nurse. Which of the following clients should the nurse identify as being a candidate for antidepressant therapy?

Rationale: A. A client who has decreased urine cortisol levels: Hypercortisolism or dysregulated cortisol is more commonly linked to depressive symptoms, so decreased levels would not indicate a primary need for antidepressant therapy. B. A client who has decreased interleukin-6 levels: Interleukin-6 is an inflammatory marker, and elevated levels have been associated with depression. Decreased IL-6 does not indicate inflammation-related depression or a need for antidepressants. C. A client who has decreased C-reactive protein levels: Low C-reactive protein indicates minimal systemic inflammation. Since elevated CRP can correlate with depressive states, decreased CRP does not identify a candidate for antidepressant therapy. D. A client who has decreased serotonin levels: Reduced serotonin is linked to depressive disorders. Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), aim to increase serotonin availability in the brain, making this client an appropriate candidate for therapy.