A nurse is discussing antidepressants with a newly licensed nurse. Which of the following clients should the nurse identify as being a candidate for antidepressant therapy?

A. Interleukin-6 is a marker of inflammation, not a direct indicator for antidepressant therapy. B. Depression is linked to decreased serotonin, norepinephrine, and dopamine levels. Antidepressants (SSRIs, SNRIs, TCAs, MAOIs) act by increasing serotonin availability, improving mood and energy levels. C. C-reactive protein relates to inflammation and infection, not mood disorders. D. Urine cortisol levels may reflect stress but are not diagnostic for depression.