A nurse is educating a client about a new prescription for celecoxib.Which of the following information should the nurse include in the teaching about the medication's mechanism of action?
Explanation & Rationale
Choice A rationaleCelecoxib does not inhibit the histamine response. Histamine is involved in allergic reactions, and celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that targets specific enzymes involved in inflammation.Choice B rationaleCelecoxib specifically inhibits COX-2, an enzyme involved in the inflammation pathway. This selective inhibition helps reduce inflammation and pain without significantly affecting COX-1, which is protective for the stomach lining.Choice C rationaleCOX-1 is not the primary target of celecoxib. Inhibition of COX-1 can lead to gastrointestinal side effects, which celecoxib aims to minimize by selectively inhibiting COX-2 instead.Choice D rationaleCelecoxib does not inhibit beta receptors. Beta receptors are involved in cardiovascular responses, and beta blockers are used for conditions like hypertension, not inflammation.