A nurse is educating a client about pain management with opioids. Which of the following information should the nurse include?

A. Diarrhea is a common adverse effect of opioids. This statement is incorrect. Opioids commonly cause constipation, not diarrhea, as they slow down gastrointestinal motility. B. Opioids can increase urinary output. This statement is incorrect. Opioids can actually cause urinary retention rather than increasing urinary output. C. Long-term use of opioids may cause dependence. This statement is correct. Long-term use of opioids can lead to physical dependence, where the body adapts to the drug, and withdrawal symptoms occur if the drug is abruptly discontinued. D. Tolerance to opioids will require a decreased dose. This statement is incorrect. Tolerance to opioids means that over time, higher doses of the drug are needed to achieve the same level of pain relief, not a decreased dose.