A nurse is educating a client about self-administering regular insulin. The nurse should instruct the client to rotate injection sites to prevent which of the following?

A. Lipohypertrophy – This is correct. Lipohypertrophy is the thickening of subcutaneous fat that can occur from repeated insulin injections at the same site. This can interfere with insulin absorption, leading to inconsistent glucose control. Rotating injection sites prevents this complication and ensures even absorption of insulin. B. Injection pain – This is incorrect. Injection pain is typically related to technique or needle size rather than the location. Rotating injection sites does not specifically address this issue. C. Rapid absorption – This is incorrect. Rotating injection sites does not necessarily prevent rapid absorption but ensures more consistent absorption rates. D. Intradermal injection – This is incorrect. Intradermal injection occurs when the needle is not inserted deep enough, unrelated to rotating injection sites.