A nurse is explaining the pathophysiology of systemic inflammatory response syndrome (SIRS) to a group of newly licensed nurses. Which of the following statements by the nurse is accurate?

A. "A deregulated cytokine storm causes an inflammatory response.": SIRS is triggered by widespread release of pro-inflammatory cytokines (a cytokine storm), which leads to systemic inflammation and potential organ injury. B. "The major organ prone to injury during SIRS is the appendix.": The appendix is not a target organ. Organs like the lungs, kidneys, liver, and heart are typically affected in SIRS/MODS. C. "Activation of the inflammatory cascade causes increased perfusion.": SIRS typically causes capillary leak and hypotension, leading to decreased perfusion to tissues and organs. D. "Spleen dysfunction causes blood clotting issues.": While the spleen plays a role in immune function, coagulation abnormalities in SIRS are primarily due to endothelial damage and systemic inflammation, not direct spleen dysfunction.