A nurse is monitoring several clients prescribed first-generation antipsychotics. Which of the following clients requires the most immediate assessment for extrapyramidal symptoms (EPS)?

Choice A reason: Feelings of worthlessness and guilt are psychological symptoms often associated with depression. While important, they are not indicative of EPS and do not require immediate intervention related to antipsychotic side effects. Choice B reason: Dry mouth and constipation are anticholinergic side effects of antipsychotics. They are uncomfortable but not life-threatening and do not represent EPS. Choice C reason: Increased sleep and decreased appetite may indicate sedation or depressive symptoms. These are concerning but not urgent in the context of EPS monitoring. Choice D reason: Inability to sit still and agitation are signs of akathisia, a form of EPS. This requires immediate assessment and intervention because it can cause severe distress and may lead to noncompliance with treatment or self-harm. This makes it the most urgent finding.