A nurse is planning to teach a client about taking prednisone. Which of the following instructions should the nurse include?

A. Prednisone should not typically be taken on an empty stomach due to its potential to cause gastric irritation. It is best taken with food to reduce gastrointestinal discomfort. B. Prednisone should not be taken at bedtime, as it can cause insomnia and disrupt sleep patterns. C. Long-term use of prednisone can increase the risk of bone loss, so clients should be encouraged to increase their intake of calcium and vitamin D to support bone health. D. Weight gain is a more common side effect of prednisone due to its fluid-retaining properties, so the client should be monitored for weight gain rather than weight loss.