A nurse is preparing a client's insulin regimen. Which of the following insulins can be mixed? (Select all that apply.)

A. Insulin lispro: Lispro is a rapid-acting insulin that can be mixed with intermediate-acting insulins such as NPH in the same syringe. When mixing, lispro is drawn into the syringe first to maintain its rapid-acting properties and prevent contamination of the intermediate insulin. B. Insulin aspart: Aspart is another rapid-acting insulin compatible with intermediate-acting insulins like NPH for mixing. Proper technique involves drawing the rapid-acting insulin first, ensuring stable blood glucose control while reducing the number of injections. C. Regular insulin: Regular insulin is short-acting and can be mixed with NPH insulin. This combination allows for both immediate and intermediate glycemic control, making it convenient for clients requiring multiple insulin actions in a single injection. D. Insulin glargine: Glargine is a long-acting insulin that forms microprecipitates in subcutaneous tissue for steady absorption. It cannot be mixed with other insulins because mixing alters its pharmacokinetics and can compromise its peakless effect. E. Insulin detemir: Detemir is also a long-acting insulin and must be administered separately. Mixing it with other insulins can change absorption rates and efficacy, making it unsafe to combine in the same syringe.