A nurse is preparing to administer amphotericin B lipid complex 3.75 mg/kg via intermittent IV bolus to a client who weighs 167 lb. Available is amphotericin B lipid complex 300 mg in 300 mL of dextrose 5% in water. How many mL should the nurse administer? (Round the answer to the nearest whole number. Use a leading zero if it applies.)

Calculation: Convert the client's weight from pounds (lbs) to kilograms (kg): Formula: Weight in kg = Weight in lbs / 2.2 lbs/kg = 167 lbs / 2.2 lbs/kg ≈ 75.91 kg Calculate the total dose of amphotericin B lipid complex needed: Ordered dose: 3.75 mg/kg Client's weight in kg: ≈ 75.91 kg Formula: Total dose (mg) = Ordered dose (mg/kg) × Client's weight (kg) = 3.75 mg/kg × 75.91 kg ≈ 284.66 mg Determine the concentration of the available amphotericin B lipid complex solution: Available amount: 300 mg Volume of solution: 300 mL Formula: Concentration (mg/mL) = Total amount (mg) / Total volume (mL) = 300 mg / 300 mL = 1 mg/mL Calculate the volume of solution to administer: Formula: Volume to administer (mL) = Desired dose (mg) / Concentration (mg/mL) = 284.66 mg / 1 mg/mL = 284.66 mL Round the answer to the nearest whole number: 284.66 mL rounded to the nearest whole number is 285 mL.