A nurse is preparing to administer cyclosporine 5 mg/kg IV bolus to a client who weighs 143 lb. Available is cyclosporine injection 50 mg/mL. How many mL should the nurse administer? (Round the answer to the nearest tenth. Use a leading zero if it applies. Do not use a trailing zero.)

Convert the client's weight from pounds (lb) to kilograms (kg). Weight in kg = 143 lb / 2.2 lb/kg = 65 kg Calculate the total desired dose in milligrams (mg). Desired dose (mg) = Desired dose (mg/kg) × Weight (kg) = 5 mg/kg × 65 kg = 325 mg Available concentration of the cyclosporine injection = 50 mg/mL. Calculate the volume in milliliters (mL) to administer. Volume (mL) = Desired dose (mg) / Available concentration (mg/mL) = 325 mg / 50 mg/mL = 6.5 mL.