A nurse is preparing to administer darbepoetin 0.45 mcg/kg subcutaneous once weekly to a client who weighs 190 lb. The amount available is darbepoetin 300 mcg/mL. How many mL should the nurse administer? (Round the answer to the nearest tenth. Use a leading zero if it applies. Do not use a trailing zero.) ________ mL

Step 1 is to convert the client's weight from pounds (lb) to kilograms (kg) Weight in kg = 190 ÷ 2.2 190 ÷ 2.2 = 86.3636... kg Step 2 is to calculate the total dose in micrograms (mcg) Total mcg dose = Weight in kg × Dosage (mcg/kg) 86.3636... × 0.45 = 38.8636... mcg Step 3 is to calculate the volume to administer in milliliters (mL) (Ordered dose ÷ Available dose) × Available volume = Result (38.8636... ÷ 300) × 1 = Result 38.8636... ÷ 300 = 0.1295... 0.1295... × 1 = 0.1295... Step 4 is to round to the nearest tenth 0.1295... ≈ 0.1 Answer: 0.1mL