A nurse is preparing to administer digoxin oral solution 8 mcg/kg/day PO in two equally divided doses to a toddler who weighs 10 kg (22 lb). The amount available is digoxin 0.05 mg/mL. How many mL should the nurse administer with each dose? (Round the answer to the nearest tenth. Use a leading zero if it applies. Do not use a trailing zero.)

Calculation: Calculate the total daily dose in micrograms (mcg). Total daily dose (mcg) = Desired dose (mcg/kg/day) × Weight (kg) = 8 mcg/kg/day × 10 kg = 80 mcg/day. Calculate the amount to administer with each dose. Number of doses per day = 2. Dose per administration (mcg) = Total daily dose (mcg) / Number of doses per day =80 mcg/day / 2 = 40 mcg. Convert the desired dose per administration from micrograms (mcg) to milligrams (mg). Desired dose per administration (mg) = Desired dose per administration (mcg) / 1000 mcg/mg = 40 mcg / 1000 mcg/mg = 0.04 mg. Available concentration of the digoxin oral solution = 0.05 mg/mL. Calculate the volume in milliliters (mL) to administer with each dose. Volume per dose (mL) = Desired dose per administration (mg) / Available concentration (mg/mL) = 0.04 mg / 0.05 mg/mL = 0.8 mL.