A nurse is preparing to administer methotrexate in oral tablet form to a client. Which of the following actions should the nurse take?

A. Handle in an area with controlled ventilation: Controlled ventilation is generally required for aerosolized or powdered hazardous medications, not for standard oral methotrexate tablets. This level of control is unnecessary for oral administration. B. Wear an N95 mask: Respiratory protection is not required when administering oral methotrexate, as the risk of inhalation is minimal. Masks are reserved for procedures generating airborne particles of hazardous drugs. C. Don a protective gown: A protective gown is recommended if there is a risk of the medication contacting skin or clothing, such as with injectable or crushed hazardous drugs. Oral tablets taken by the client do not pose this risk. D. Apply gloves: Gloves should be worn when handling oral methotrexate tablets to prevent skin contact with the cytotoxic drug. Methotrexate is teratogenic and can be absorbed through the skin, making gloves an essential safety measure.