A nurse is preparing to administer methotrexate in oral tablet form to a client. Which of the following actions should the nurse take?

A. Don a protective gown: Wearing a gown is typically reserved for handling parenteral forms of chemotherapeutic agents or when there is a risk of body fluid exposure. For oral tablet administration, this level of protection is not routinely required. B. Apply gloves: Methotrexate is a hazardous drug, and wearing gloves when handling oral tablets protects against dermal absorption. This is the appropriate precaution to minimize the nurse’s exposure during routine administration. C. Wear an N95 mask: An N95 mask is not necessary for administering methotrexate in oral form. These masks are used for airborne precautions, such as with tuberculosis or COVID-19, not for handling tablets unless there is risk of aerosolized powder. D. Handle in an area with controlled ventilation: Controlled ventilation is necessary when preparing injectable chemotherapy drugs in a pharmacy or cleanroom. Oral tablet administration does not require this level of environmental control.