A nurse is preparing to administer naloxone (Narcan). The nurse understands that this medication has a rapid first-pass inactivation. Which of the route should the nurse NOT administer this medication?

A. Subcutaneous administration is an acceptable route for naloxone when IV access is not available. B. Intravenous administration is an effective route for naloxone, especially in emergency situations where rapid action is needed. D. Intramuscular administration is also effective and commonly used, especially in opioid overdose situations. C. Naloxone should not be administered orally because it undergoes rapid first-pass metabolism in the liver, which would significantly reduce its effectiveness.