A nurse is preparing to administer penicillin G to a client. The client reports a history of a rash after receiving amoxicillin. Which action should the nurse take?
Explanation & Rationale
A. Even a mild rash after a penicillin-class antibiotic (such as amoxicillin) can indicate an allergic reaction, and giving penicillin G without provider guidance risks a potentially severe or life-threatening reaction, including anaphylaxis. B. While monitoring is always important, administering penicillin G to someone with a reported allergy without consulting the provider is not appropriate. Severe reactions can occur rapidly and may be fatal. C. Diphenhydramine may reduce mild allergic symptoms but does not prevent a severe allergic reaction to penicillin. Pre-medication with antihistamines is not an acceptable substitute for avoiding the allergenic drug. D. The provider must be notified to evaluate the allergy history and determine an alternative antibiotic if necessary. Clients with a history of reactions to one penicillin are at increased risk for cross-reactivity with other penicillin-class medications. Safety requires consultation before administration.