A nurse is preparing to administer perphenazine 0.032 g PO divided in four equal doses daily to a client who has psychosis. Available is perphenazine oral solution 16 mg/5 mL. How many mL should the nurse administer per dose? ( Round to the nearest tenth. Use a leading zero if it applies. Do not use a trailing zero.)
Explanation & Rationale
Calculate the Individual Dose: The total daily dose is 0.032 grams (g) of perphenazine. This is divided into four equal doses. Individual dose: 0.032 g / 4 = 0.008 g Convert Grams to Milligrams: Convert the dose to milligrams (mg). There are 1000 milligrams in 1 gram (1 g = 1000 mg). So, 0.008 g x 1000 mg/g = 8 mg Determine the Volume per Dose: The available concentration is 16 mg/5 mL. We need to find the volume (in mL) that contains 8 mg. Set up the Proportion or Use the Formula: Proportion Method: 16 mg / 5 mL = 8 mg / x mL 16x = 40 x = 40 / 16 x = 2.5 mL Formula Method: Volume (mL) = (Desired Dose (mg) / Available Concentration (mg)) x Volume of Available Solution (mL) Volume (mL) = (8 mg / 16 mg) * 5 mL Volume (mL) = 0.5 x 5 mL Volume (mL) = 2.5 mL Round to the Nearest Tenth: 2.5 mL