A nurse is providing an in-service for hydrochlorothiazide (Hydro Diuril). Which of the following statements are TRUE regarding hydrochlorothiazide? (Select All That Apply).

A. Hydrochlorothiazide is a thiazide diuretic that works in the distal convoluted tubule of the kidney. It inhibits the reabsorption of sodium and chloride, leading to increased excretion of water, sodium, and chloride. B. Hydrochlorothiazide is often the first-line treatment for hypertension because it helps reduce blood pressure through diuresis (increased urine output), which reduces fluid volume in the body. C. Urinary retention is not a known complication of hydrochlorothiazide. Instead, it may cause frequent urination due to its diuretic effect. D. Hydrochlorothiazide does not interact with opioids in a way that would cause opioid toxicity. It primarily affects sodium and water balance in the body.