A nurse is providing teaching for a client who has a new prescription for alprazolam to treat insomnia. Which of the following instructions should the nurse include?

Choice A reason: Alprazolam does not require administration with food, and taking it with a high-fat meal may actually delay absorption. This instruction is not appropriate. Choice B reason: Peripheral edema is not a common adverse effect of alprazolam. Monitoring for this symptom is not a standard teaching point for benzodiazepines. Choice C reason: Alprazolam is a benzodiazepine that causes sedation, drowsiness, and impaired coordination. Patients should avoid activities requiring alertness, such as driving or operating heavy machinery, to prevent accidents. This is the most important teaching point. Choice D reason: Alprazolam should be taken as prescribed, but it is not always recommended to take it nightly before sleep because of the risk of dependence. The nurse should emphasize adherence to the provider’s instructions rather than routine nightly use.