A nurse is providing teaching to a client who has a new prescription for rifampin. Which of the following statements should the nurse include in the teaching?

A. “You should take this medication once each day at bedtime.” This statement is incorrect because rifampin is typically taken on an empty stomach, either 1 hour before or 2 hours after a meal, to ensure optimal absorption. Taking it at bedtime is not a standard recommendation. B. “You can continue to wear soft contact lenses while taking this medication.” This statement is incorrect because rifampin can cause discoloration of bodily fluids, including tears, which can stain soft contact lenses. Patients are usually advised to avoid wearing soft contact lenses during treatment. C. “This medication will not interfere with the effectiveness of oral contraceptives.” This statement is incorrect because rifampin is known to reduce the effectiveness of oral contraceptives. Patients should be advised to use an alternative or additional form of contraception while taking rifampin. D. “Your urine will turn orange while you are taking this medication.” This statement is correct. Rifampin commonly causes a harmless discoloration of urine, sweat, saliva, and tears to an orange or reddish color. Patients should be informed about this side effect to avoid unnecessary concern.