A nurse is providing teaching to a client who has a new prescription for rifampin. Which of the following statements should the nurse include in the teaching?

A. "Your urine will turn orange while you are taking this medication." Rifampin commonly causes harmless discoloration of body fluids, including urine, sweat, saliva, and tears, turning them orange or reddish-orange. Clients should be informed in advance to prevent alarm and ensure adherence to therapy. B. "This medication will not interfere with the effectiveness of oral contraceptives.": Rifampin induces hepatic enzymes that accelerate the metabolism of estrogen-based contraceptives, reducing their effectiveness. Clients should be advised to use alternative or additional non-hormonal contraceptive methods while on the drug. C. "You should take this medication once each day at bedtime.": While rifampin is often taken once daily, the timing is usually recommended to be on an empty stomach, either one hour before or two hours after a meal, to maximize absorption. Bedtime is not specifically indicated and might not always coincide with an empty stomach. D. "You can continue to wear soft contact lenses while taking this medication.": Rifampin can discolor soft contact lenses due to pigment in tears, possibly causing permanent staining. Clients are advised to switch to glasses during therapy or use disposable lenses to avoid discoloration.