A nurse is providing teaching to a client who has erectile dysfunction and has a new prescription for tadalafil. Which of the following client statements indicates an understanding of the teaching?

Choice A rationale Tadalafil, like many extended-release or film-coated tablets, should be swallowed whole. Crushing the tablet can alter its pharmacokinetics, leading to a faster absorption and a higher peak plasma concentration, which increases the risk of side effects and may compromise its intended duration of action. Choice B rationale Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor. It works by causing vasodilation in the smooth muscles of the corpus cavernosum, which can also lead to systemic vasodilation. This effect can lower blood pressure, making this statement a correct understanding of a potential side effect. Choice C rationale Tadalafil's long half-life of 17.5 hours allows it to be taken once daily. The standard daily dose is 2.5 to 5 mg, and it should not be taken more than once every 24 hours. Taking it twice a day would significantly increase the risk of hypotensive and other adverse effects. Choice D rationale Tadalafil is known for its long duration of action, with effects lasting up to 36 hours, earning it the nickname "the weekend pill.”. This is in contrast to other PDE5 inhibitors like sildenafil, which typically last around 4 hours. The client's statement indicates a misunderstanding.