A nurse is providing teaching to a client who has stable angina and a new prescription for transdermal nitroglycerin. Which of the following instructions should the nurse include? (Select all that apply.)

A. Remove the patch for 10 to 12 hours daily: Transdermal nitroglycerin patches are typically worn for 12-14 hours and then removed for a patch-free period (usually 10-12 hours) to prevent tolerance from developing to the medication. B. Apply the patch to dry skin and cover the area with plastic wrap: The patch should be applied to dry skin, but it should not be covered with plastic wrap. The adhesive patch itself is designed to adhere to the skin without additional covering, plastic wrap can interfere with proper absorption. C. Apply the patch to a hairless area and rotate sites: The patch should be applied to a hairless area of the skin to ensure good adhesion and absorption. Rotating the sites helps prevent skin irritation and allows for proper drug absorption without constant irritation to the same area. D. Apply a new patch each morning: A new patch should be applied each day, typically in the morning, to maintain continuous coverage of nitroglycerin over a 12-14 hour period. E. Apply a new patch at the onset of anginal pain: The transdermal nitroglycerin patch is used as a preventive measure for angina and is not intended for immediate relief of acute anginal attacks. For acute attacks, the client should use sublingual nitroglycerin or as prescribed for rapid relief.