A nurse is providing teaching to a female client who is taking conjugated equine estrogens (Premarin). Which of the following clients are contraindicated for conjugated equine estrogens (Premarin)? (Select All That Apply).

A. A client with a history of thromboembolic disease: Estrogen therapy is contraindicated in clients with a history of thromboembolic disease due to the increased risk of blood clots. B. A client with a history of hypertension: Hypertension is a relative contraindication, but it may still be prescribed with caution. C. A client with a history of depression: Depression is not a contraindication to estrogen therapy. D. A client with atypical vaginal bleeding that is not diagnosed: Unexplained vaginal bleeding should be investigated before administering estrogen therapy.