A nurse is reinforcing teaching about insulin injections with a client who is newly diagnosed with type I diabetes mellitus. Which of the following information should the nurse include about site selection?

A. Rotating injection sites within the same general area helps prevent lipohypertrophy, which is the development of fatty lumps due to repeated insulin injections in the same spot. Proper rotation ensures consistent absorption of insulin and maintains skin integrity. Common rotation sites include the abdomen, thighs, upper arms, and buttocks. B. Insulin is absorbed most rapidly from the abdomen, followed by the arms, thighs, and buttocks. Injecting into the thigh results in slower absorption, which can affect glycemic control if timing is critical, such as before meals. C. Insulin should be allowed to reach room temperature before injection. Cold insulin can increase discomfort and pain at the injection site. Letting insulin warm slightly reduces injection pain and makes administration easier. D. Massaging the injection site is not recommended, as it can alter insulin absorption, cause bruising, or irritation, and may contribute to tissue trauma. Insulin should be injected and left undisturbed for proper absorption.