A nurse is reinforcing teaching about the iPLEDGE program with a female client who has a new prescription for isotretinoin.The nurse should tell the client that which of the following is a requirement of the program?

Choice A rationale:A negative mammogram is not a requirement of the iPLEDGE program. Mammograms are used to screen for breast cancer and are not related to isotretinoin therapy.Choice B rationale:Regular Papanicolaou tests, which screen for cervical cancer, are not a requirement of the iPLEDGE program. These tests are not related to isotretinoin therapy.Choice C rationale:There is no requirement for clients to begin a daily supplement of vitamin A prior to initiating therapy. In fact, taking additional vitamin A while on isotretinoin can increase the risk of vitamin A toxicity.Choice D rationale:Sexually active female clients must use two forms of birth control during treatment. This is because isotretinoin can cause severe birth defects.