A nurse is reinforcing teaching to a student nurse about chronic myelogenous leukemia (CML). Which of the following should the nurse include in the teaching as risk factors for this condition? (Select All that Apply.)

A. Being a white male: Statistically, CML is slightly more common in males than females and has a higher incidence in white populations. B. Hormone therapy: There is no established clinical link between hormone replacement therapy and the development of CML. C. Chemotherapy: Previous treatment with certain chemotherapy agents for other cancers can increase the risk of developing secondary leukemias, including CML. D. Under the age of 50 years old: CML is primarily a disease of older adults, with the average age of diagnosis being around 64. It is rare in children and young adults. E. Radiation exposure: Exposure to high-dose radiation (such as atomic bomb survivors or nuclear accidents) is a well-documented risk factor for CML.