A nurse is reinforcing teaching with a client who has a new prescription for enoxaparin. The nurse should identify which of the following over-the-counter products as unsafe for use with enoxaparin.

A) Cimetidine: Cimetidine is an H2 receptor antagonist used to treat gastrointestinal issues like heartburn or ulcers. It does not have a known significant interaction with enoxaparin. Therefore, it is generally considered safe to use with enoxaparin, but it may require monitoring for other potential drug interactions, such as those with warfarin, not enoxaparin specifically. B) Docusate: Docusate is a stool softener commonly used to prevent constipation. It does not interact with enoxaparin and is safe for use with the medication. It helps relieve constipation without increasing bleeding risks, which is a concern with certain other medications. C) Calcium supplement: Calcium supplements are generally safe to use with enoxaparin. There is no significant interaction between calcium and enoxaparin, and calcium is often recommended for clients to maintain bone health, especially in those who are at risk of osteoporosis. Therefore, calcium supplements do not pose a risk when taken with enoxaparin. D) Naproxen: Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that increases the risk of bleeding. NSAIDs, including naproxen, inhibit platelet aggregation, which can potentiate the anticoagulant effects of enoxaparin and increase the risk of bleeding. Therefore, naproxen should be avoided in clients taking enoxaparin.