A nurse is reinforcing teaching with a client who has a new prescription for transdermal nitroglycerin patches. Which of the following statements indicates an understanding of the teaching?

The client should choose a clean, dry, hairless area of skin to apply the patch. It is important to rotate the application site to avoid skin irritation and ensure consistent drug absorption. The patch should be replaced every 24 hours, not every 12 hours. If the client experiences a headache, it is not necessary to remove the patch, as headaches can be a common side effect of nitroglycerin use. Applying the patch in the same place every day can lead to skin irritation and decreased absorption.